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Neuroticism has also been studied from the perspective of Gray's biopsychological theory of personality, using a scale that measures personality along two dimensions: the behavioural inhibition system (BIS) and the behavioural activation system (BAS).

Mood disorders tend to have a much larger association with neuroticism than most other disorders.

Self-report measures are either lexical Deciding which measure of either type to use in research is determined by an assessment of psychometric properties and the time and space constraints of the study being undertaken.

Lexical measures use individual adjectives that reflect neurotic traits, such as anxiety, envy, jealousy, and moodiness, and are very space and time efficient for research purposes.

People with high neuroticism indexes are at risk for the development and onset of common mental disorders, Galen of Pergamom popularized the idea that mixes of four bodily fluids or humours resulted in four personality types or temperaments.

The melancholic personality type, which can be seen as the conceptual predecessor of neuroticism, was characterized by being mentally unbalanced, fearful, anxious, or sad.

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